Estrogen Receptor (ER) PROTAC Degrader Arv471 CAS NO.2229711-68-4

Min.Order: 100 Gram
Payment Terms: L/C,D/P,T/T,MoneyGram

Product Details

Keywords

Estrogen Receptor (ER) PROTAC Degrader
2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-ph enyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-
Arv471

Quick Details

ProName: Estrogen Receptor (ER) PROTAC Degrader...
CasNo: 2229711-68-4
Molecular Formula: C45H49N5O4
Appearance: White to off-white (Solid)
Application: ARV-471 is a best-in-class, orally act...
DeliveryTime: 20 days after receiving the deposits
PackAge: based on your requests.
Port: Tianjin/Qingdao/Ningbo/Shanghai/Guangz...
ProductionCapacity: 500 Kilogram/Year
Purity: 99.60%
Storage: -20°C, sealed storage, away from moi...
Transportation: Room temperature in continental US; ma...
LimitNum: 100 Gram
Moisture Content: AS COA
Impurity: As COA
Molecular Fomula: C45H49N5O4
Molecular Weight: 723.90

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3) OEM/ODM is available; we have professional engineer to design the fomulation with you together.

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4. Method of Aanlysis (MOA)

5. Nuclear Magnetic Resonance (NMR)

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Details

Estrogen Receptor (ER) PROTAC Degrader Arv471

About US	Xinyang Longye Chemical Products Co., Ltd. is a high-tech enterprise integrating science, industry and trade, and holds a certain authoritative position in the brightener chemical industry. It mainly develops and sells fluorescent brighteners, pharmaceutical intermediates, electronic chemical products and other fine chemical products, which are widely used in medicine, electronics, environmental protection, plastics, textiles, daily chemicals and other fields. After hundreds of users use, it has received praise and trust from customers.
Description	ARV-471 is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
Applicaiton	Usage: Estrogen Receptor/ERR; PROTACs Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC₅₀) of ~2 nM
Packing	1. Free samples are available 2. small quanity will be sent by courior or air, mass production will ship by sea 3. by carton or based on your requirements.
Chemical Experience	RD Engineer and sales engineer have more than 20 years experience in chemicals and pharmaceitical intermediates
Market	China, India